Abstract
The data on the histological type of carcinomatous component and the extent of extracapsular invasion for salivary carcinomas ex pleomorphic adenoma (PA) are conflicting. We aimed to determine the prognostic value of extracapsular invasion in salivary duct carcinomas (SDC) ex PA. A total of 117 patients with SDC were identified retrospectively; 44 cases involving major salivary glands had pre-existing PA (44 of 117, 37%). The morphological spectrum of SDC ex PA was characterized. The primary endpoint was overall survival (OS). Most SDC ex PA were widely invasive at presentation (27 of 44; 61%). Five patients with intracapsular SDC ex PA experienced no disease progression. The assessment of extracapsular invasion was precluded in eight cases (e.g. positive margins of resection). The rate of lymph node involvement was similar in cases with extracapsular invasion of ≤2mm (two of three) and >7mm (22 of 26). Only pT correlated with OS [116months, 95% confidence interval (CI) 22-210months for pT1 versus 20months (95% CI 6-34) for pT4; P=0.013]. Intracapsular SDC ex PA are potentially indolent. SDC ex PA with extracapsular invasion of ≤2mm are rare, and appear to be clinically aggressive. Several histological parameters preclude assessment of extracapsular invasion.
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