Abstract
The administration of systemic and nebulized corticosteroids to VLBW infants is beneficial in the treatment of bronchopulmonary dysplasia (BPD). Side effects and complications are frequent and sometimes serious. The aim of the study was to investigate the effect of systemic dexamethasone and nebulized budesonide on adrenal function in infants with BPD using salivary samples. Methods: We measured salivary cortisol levels by RIA in saliva in four groups: (1) ten full-term neonates; (2) ten healthy preterm infants (GA 28-31 wks); (3) ten infants with BPD after 16 days of systemic dexamethasone treatment (24-28 wks); and (4) 10 infants with BPD after 5 days of nebulized budesonide (26-35 wks). Saliva samples were collected in each infant on three consecutive days at 8.00, 12.00, 18.00, 24.00 hours. Results: Our results show suppression of the adrenal function in infants treated with systemic dexamethasone and less pronounced with nebulized budesonide. The results are mean ± SEM (ng/ml).Table
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