Salivary carcinoembryonic antigen as an inflammatory marker

Abstract

In this study we examined concentration of carcinoembryonic antigen (CEA) in paired saliva and serum samples from healthy individuals and patients with periodontal disease. CEA concentration was determined immunoradiometrically using highly specific anti-CEA antibodies. The salivas from periodontally healthy subjects revealed CEA concentrations with median value of 62 mg/L. Distribution of salivary CEA concentrations in patients with periodontal diseases were very broad with median values: 74 mg/L (stage I), 84 mg/L (stage II), 240 mg/L (stage III) and 412 mg/L (necrotizing ulcerative periodontitis-NUP). Analysis of the obtained values indicated statistically significant increase in salivary CEA, in subjects with periodontal diseases. Metronisadole treatment in patients with NUP leads to statistically significant decrease in salivary CEA. The results obtained suggested salivary CEA as a potential marker of the alterations of periodontium.