Year-end Sale % OFF 
Abstract
Salivary levels of biomarkers for the hypothalamic–pituitary–adrenal axis (HPA; cortisol) and sympatho-adreno-medullary system (SAM; α-amylase) were measured in 51 adults (57% male) with neurodevelopmental disorders associated with intellectual disability (i.e., mental retardation) and chronic self-injurious behavior (SIB) and compared with matched controls without SIB. Cortisol levels differed significantly (p < 0.01) between the SIB and control group (SIB > control). Within-group analyses showed significant differences (p < 0.05) in levels of salivary α-amylase between individuals with SIB and those with SIB meeting criteria for stereotyped movement disorder (SMD; SIB + SMD > SIB). Salivary α-amylase was significantly correlated with frequency of stereotypy among the SIB group (r = 0.36, p < 0.05). These preliminary findings warrant further exploration into the role of the SAM system in the pathophysiology of SIB and related repetitive behaviors among individuals with neurodevelopmental disorders associated with intellectual disability.
Highlights
Salivary levels of biomarkers for the hypothalamic– pituitary–adrenal axis (HPA; cortisol) and sympatho-adrenomedullary system (SAM; α-amylase) were measured in 51 adults (57% male) with neurodevelopmental disorders associated with intellectual disability and chronic self-injurious behavior (SIB) and compared with matched controls without SIB
Males comprised 62% of the SIB group and 47% of the control group; 8% of the sample functioned in the moderate range of mental retardation; 10% of the sample functioned in the severe range of mental retardation, and 82% of the sample functioned in the profound range of mental retardation
A number of demographic, procedural, and SIB variables were examined to determine whether they were associated with the biomarker variables
Summary
Salivary levels of biomarkers for the hypothalamic– pituitary–adrenal axis (HPA; cortisol) and sympatho-adrenomedullary system (SAM; α-amylase) were measured in 51 adults (57% male) with neurodevelopmental disorders associated with intellectual disability (i.e., mental retardation) and chronic self-injurious behavior (SIB) and compared with matched controls without SIB. Salivary αamylase was significantly correlated with frequency of stereotypy among the SIB group (r=0.36, p
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
