Abstract

Total Antioxidant Capacity (TAC) is a biomarker often used in order to investigate oxidative stress in many pathological conditions. Saliva and urine can be collected noninvasively and represent attractive diagnostic fluids for detecting biomarkers of various pathological conditions. The reviewed case-control and intervention studies that measured salivary or urinary TAC revealed that diseases, antioxidant foods, or supplements and age, gender, and lifestyle factors influenced salivary or urinary TAC. Salivary and urinary TAC were particularly affected by oral or renal status, respectively, as well as by infection; therefore these factors must be taken into account in both case-control and intervention studies. Furthermore, some considerations on sample collection and normalization strategies could be made. In particular, unstimulated saliva could be the better approach to measure salivary TAC, whereas 24 h or spontaneous urine collection should be chosen on the basis of the study outcome and of the creatinine clearance. Finally, the uric acid-independent TAC could be the better approach to evaluate red-ox status of body, in particular after nutritional interventions and in diseases associated with hyperuricaemia.

Highlights

  • Oxidative stress, defined as the imbalance between Reactive Oxygen Species (ROS) production and antioxidant defense inside human organism, is a risk factor playing a significant pathogenetic role for noncommunicable diseases [1]

  • The uric acid-independent Total Antioxidant Capacity (TAC) could be the better approach to evaluate red-ox status of body, in particular after nutritional interventions and in diseases associated with hyperuricaemia

  • Total Antioxidant Capacity (TAC), defined as the moles of oxidants neutralized by one litre of solution, is a biomarker measuring the antioxidant potential of body fluids [4]

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Summary

Introduction

Oxidative stress, defined as the imbalance between Reactive Oxygen Species (ROS) production and antioxidant defense inside human organism, is a risk factor playing a significant pathogenetic role for noncommunicable diseases [1]. It has been suggested that saliva could constitute a first line of defense against free radicalmediated oxidative stress [11], whereas the composition of urine reflects the continuously changing environment of the body, which is affected, among other factors, by diet and in particular by polyphenol metabolites excreted in urine [12]. We aimed to review case-control and intervention studies that measured salivary [13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138] or urinary [138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154,155,156,157,158,159,160,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177,178,179] TAC

Infection and Oral and Renal Status
Systemic Diseases
Nutritional and Supplement Interventions
Methodological Issues
Uric Acid-Independent TAC versus TAC
Conclusion
Findings
Conflict of Interests
Full Text
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