Abstract
The psychological stress of most perioperative patients has been reduced by many interventions. In order to evaluate the effects of these interventions, biomarkers are being considered as objective assessment tools in addition to the subjective assessment tools. It has been thought that salivary α-amylase (sAA) activity is associated with sympathetic nervous system activity, which reflects psychological stress. We examined the relationship between sAA, self-reported data, and autonomic nervous system activity to assess the reliability of sAA as a marker for relaxing response in surgery-related stress. The sAA, the State anxiety, Visual Analogue Scale (VAS) of pain, and heart rate variability were used to assess prior to and after the relaxation on the day before surgery, and on postoperative days (POD) 1, 2, 3, and 7. A total of 75 patients participated and 301 relaxing response readings were obtained. We found that the sAA significantly decreased depending upon the pain and anxiety by relaxation, but they were unrelated to sympathetic nervous system activity. There was weak correlation between the change in sAA, and anxiety and VAS pain. Thus, sAA appears to be an easy-to-use, non-invasive and good marker for relaxing response within a short period in surgery-related stress patients.
Highlights
The psychological stress that most perioperative patients feel has been reduced by many interventions, including providing information [1,2], relaxation [3,4], hypnosis [5], and massage therapy [6]
It has been thought that salivary α-amylase activity is associated with sympathetic nervous system activity, which reflects psychological stress
We examined the relationship between salivary α-amylase (sAA), self-reported data, and autonomic nervous system activity to assess the reliability of sAA as a marker for relaxing response in surgery-related stress
Summary
The aim of this current study is to investigate the relationships between sAA, self-reported pain and anxiety, and autonomic nervous system function in perioperative patients. The aim of this study was to investigate the application of sAA in assessing the relaxation response in perioperative patients
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