Saliva As An Alternative Fluid For Kidney Diseases Assessment

Abstract

Background The prevalence of kidney diseases are increasing by increasing of chronic debilitating diseases and progressing age of population. Many medical and scientific studies increasingly encourage to use saliva fluid as an alternative fluid for diagnostic methods. Thus, the aim of the present study is to determine the diagnostic efficacy of saliva in kidney disease patients. Materials and methods A cross-sectional study included 59 patients with renal disease and 20- matched healthy controls were studied. Serum and saliva were collected and Serum and saliva were used for biochemical analysis of urea, creatinine, uric acid, total protein, albumin, sodium, potassium, calcium, and chloride, using the suitable demonstrated methods, which were statistically compared and analyzed by using SPSS version 22, student T-test. Results In the comparison of serum to salivary creatinine, uric acid, urea, albumin, total protein, sodium, potassium, calcium, chloride, the results showed a statically significance (p<0.05) in renal failure, nephritis and kidney stones patients comparing with the control subjects. Conclusion Saliva can be applied as a diagnostic fluid instead of using blood, because it is noninvasive and has an easy collection procedure, for biochemical diagnostic of renal & kidney diseases. Key words: Saliva, creatinine, urea, uric acid, T. protein, Albumin, Sodium, Potasium, Calcium & Chloride, Renal Diseases