Abstract
Background and Aim: Delayed detection of SARS-CoV-2 has been a major hindrance in curbing the current COVID-19 pandemic. Wide spread testing is the most practical way out of the current crisis. The current gold standard for COVID-19 diagnosis is real-time reverse transcription polymerase chain reaction (RT-PCR) detection of SARS-CoV-2 from nasopharyngeal swabs. However, collecting nasopharyngeal swabs causes discomfort to patients due to the procedure’s invasiveness, limiting compliance for repeat testing, and the procedure presents a considerable risk to healthcare workers. Therefore, developing rapid and convenient ways of testing for COVID-19 will greatly enhance the capacity of testing. Alternatively, saliva is a promising candidate for SARS-CoV-2 diagnostics. The purpose of this review is to provide an update and review of the composition of the latest research and to compare the various methods and techniques developed for the diagnosis of COVID-19 by saliva.
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