Saliva and urine fluoride responses to daily doses of fluoride

Abstract

abstract Five subjects were administered 28 consecutive daily oral doses of 10 nig fluoride as NaF. Placebo weeks preceded and followed the dosage period. Urine and stimulated parotid saliva were collected on a Monday through Friday pattern. Fluoride concentration in both urine and saliva was determined by specific ion electrode. Fluoride dosage brought about a 13‐fold increase in urinary F excretion. Urinary F excretion accounted for 35.3 % of the 10 nig daily dose. There was no pattern suggesting a significant antecedent dosage effect on F excretion. Salivary F levels responded rapidly and reproducibly from week to week while dosage continued. As with the urine, there was no significant indication of an effect of antecedent dosage on the salivary response curve. At 8 hours after F dosage, the salivary F mean was about four times that for the placebo week. Even at: 24 hours after dosage, the mean for salivary F was approximately three times the placebo level. Thus, there is a residual 24‐hour effect of the F dosage pattern utilized in the present study. Whether or not these persistent low‐level increases are protective to the continuously bathed tooth surfaces over a long period of time is under study.