Abstract
We have studied the effects of acute normobaric hypoxia in the early postnatal period of the development (the 2nd postnatal day) on learning and memory abilities and the expression of GABAB receptors in the neocortex (medial prefrontal cortex) in adolescent rats (the 55–60th postnatal day), as well as the possibility of correction of the revealed impairments by GABA derivative salifen. It was shown that perinatal hypoxia disrupts task acquisition and consolidation in the novel object recognition test, impairs passive avoidance performance, and also reduces spatial learning abilities in the Morris water maze. Western blotting analysis revealed increased levels of GABAB receptor protein in the medial prefrontal cortex of the rats following the exposure to perinatal hypoxia. Post-hypoxic daily salifen injections over 14 days at a dose of 15 mg/kg improved cognitive abilities in rats, and also normalized GABAB receptor content in the rat medial prefrontal cortex. The results of the present research are of considerable significance for solution of applied problem of neonatology – the search for effective drug candidates for the pharmacological correction of the impacts of perinatal hypoxia.
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