Abstract
Purpose: In Parkinson’s disease with mild cognitive impairment (PD-MCI), we investigated the clinical significance of salience network (SN) in depression and cognitive performance.Methods: Seventy seven PD-MCI patients that fulfilled multi-domain and non-amnestic subtype were included. Gray matter structural covariance networks were constructed by 3D T1-magnetic resonance imaging and seed based analysis. The patients were divided into two groups by psychiatric interviews and screening of Geriatric Depression Scale (GDS): PD-MCI with depression (PD-MCI-D) or without depression (PD-MCI-ND). The seed or peak cluster volume, or the significant differences in the regression slopes in each seed-peak cluster correlation, were used to evaluate the significance with the neurobehavioral scores.Results: This study is the first to demonstrate that the PD-MCI-ND group presented a larger number of voxels of structural covariance in SN than the PD-MCI-D group. The right fronto-insular seed volumes and the peak cluster of left lingual gyrus showed significant inverse correlation with the Geriatric Depression Scale (GDS; r = -0.231, P = 0.046).Conclusions: This study is the first to validate the clinical significance of the SN in PD-MCI-D. The right insular seed value and the SN correlated with the severity of depression in PD-MCI.
Highlights
Parkinson’s disease with mild cognitive impairment (PD-MCI) is conceptualized as a transitional state between normal cognition and dementia, it is a major predictor for the conversion of dementia (Domellof et al, 2015)
The PD-MCI was lower than the normal control (NC) in Mini-Mental State Examination (MMSE) scores (p = 0.003), scores in digital forward and backward, lower semantic verbal fluency scores and higher Geriatric Depression Scale (GDS) than NC (P < 0.05)
The right superior occipital and frontal gyri and the left supramarginal gyrus were highlighted for the difference in regional brain volume observed in the PD-MCI-D and PD-MCI-ND groups when compared with the NC group (p < 0.001)
Summary
Parkinson’s disease with mild cognitive impairment (PD-MCI) is conceptualized as a transitional state between normal cognition and dementia, it is a major predictor for the conversion of dementia (Domellof et al, 2015). For PD-MCI, the natural history of PD-MCI-D does not parallel that of motor symptoms, suggesting the distinctive pathophysiological mechanism (Brown and Jahanshahi, 1995). In this context, it is of clinical relevance to explore the neural basis of PD-MCI-D. In Parkinson’s disease, the salience network (SN) has been implicated in emotional processing and depression (Remy et al, 2005). The reduced Blood oxygenation level dependent (BOLD) response and reduced gray matter (GM) volume within the SN in Parkinson’s disease have been reported to mediate the emotional valence (Cardoso et al, 2009; Kostic et al, 2010). Despite the solid evidence of SN in PD with depression (Beyer et al, 2007; Kostic et al, 2010; Song et al, 2011), whether the changes in the SN mediate the depression state in PD-MCI is not fully investigated
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
