Abstract
In this report the paralyzing and antistrychnine activities of salicylamide derivatives were comparatively examined in mice and rabbits. Aromatic acid amides with an alkoxy group in the ortho position possessed the strongest activities. Methyl or dimethyl substitution on the N atom in the acid amide group destroyed the potency. From the results, it may be concluded that the presence of a hydroxy or alkoxy group in the ortho position as well as a free acid amide group seems to play an important role so that salicylamide derivatives may possess above described activities.
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