Salicylaldehydes in Strecker Reaction: Synthesis of Tricyclic Benzofuro[2,3‐b]pyrazin‐2(1H)‐ones via One‐Pot Seven Domino Reactions

Abstract

The current study reports the first Strecker reaction with salicylaldehydes as carbonyl compounds. This pseudo‐five‐component reaction involved two moles of salicylaldehyde, two moles of cyanide, and one mole of amine, which reacted together in ethanol at reflux conditions, resulting in the tricyclic products benzofuro[2,3‐b]pyrazin‐2(1H)‐one (4a‐v). The benzofuro[2,3‐b]pyrazin‐2(1H)‐one products were formed via one‐pot seven Domino reactions including the Strecker reaction/ intramolecular cyclization/ tautomerization of imine to enamine/ Strecker reaction/ intramolecular cyclization/ conversion of amidine to amide/ and aerobic oxidation.