Abstract
Salvianolic acid B is one of the main water-soluble components of Salvia miltiorrhiza Bge. Many reports have shown that it has significant anti-myocardial ischemia effect. However, the underlying mechanism remains unclear. Our present study demonstrated that Sal B could alleviate myocardial ischemic injury by inhibiting the priming phase of NLRP3 inflammasome. In vivo, serum c-troponin I (cTn), lactate dehydrogenase (LDH) levels, the cardiac function and infract size were examined. We found that Sal B could notably reduce the myocardial ischemic injury caused by ligation of the left anterior descending coronary artery. In vitro, Sal B down-regulated the TLR4/NF-κB signaling cascades in lipopolysaccharide (LPS)-stimulated H9C2 cells. Furthermore, Sal B reduced the expression levels of IL-1β and NLRP3 inflammasome in a dose-dependent manner. In short, our study provided evidence that Sal B could attenuate myocardial ischemic injury via inhibition of TLR4/NF-κB/NLRP3 signaling pathway. And in an upstream level, MD-2 may be the potential target.
Highlights
Data showed that cardiovascular disease (CVD) is the main cause of death nowadays [1].Myocardial ischemia plays an important role in it
Salvianolic acid B (Sal B) is a phenolic acid isolated from Salvia miltiorrhiza Bge
Results showed that the with protein of TLR4/Myd88/IRAK1/NF-κB/NLRP3 were significantly increased after modelling compared the expression levels of TLR4/Myd88/IRAK1/NF-κB/NLRP3 were were significantly increased after modelling control group
Summary
Data showed that cardiovascular disease (CVD) is the main cause of death nowadays [1]. Inhibiting the activation of TLR4/NF-κB signaling pathway contributes to reducing the expression of many pro-inflammatory cytokines and mitigating myocardial ischemia [5,6,7]. Salvianolic acid B (Sal B) is a phenolic acid isolated from Salvia miltiorrhiza Bge. Salvianolic acid B (Sal B) is a phenolic acid isolated from Salvia miltiorrhiza Bge It has been phase during acute myocardial ischemia is sufficient to inhibit the inflammasome and protecting heart shown to have a variety of pharmacological activities, such as antioxidant [11], anti-myocardial function [10]. Whether Sal Bischemia could [12], reduce to have a variety of pharmacological activities, such as antioxidant [11], anti-myocardial myocardial ischemia injury by inhibiting the activation of NLRP3 inflammasome remains anti-tumor [13], anti-inflammatory activities [14]. The present study was designed underlying to investigate the anti-myocardial ischemic effect of Sal B and explore its underlying mechanism
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