Sageretia thea (Osbeck.) mediated synthesis of zinc oxide nanoparticles and its biological applications.

Abstract

To investigate the physical and biological properties of bioinspired zinc oxide (ZnO) nanoparticles via aqueous leaf extracts of Sageretia thea. Nanoparticles of size approximately 12.4 nm were extensively characterized. In vitro antimicrobial, cytotoxic, biocompatible and enzyme inhibition assays were performed. Significant antimicrobial activities with and without UV illumination are reported. Bioinspired ZnO nanoparticles were found effective against fungal strains. MTT assay was performed to check the leishmanicidal activity against promastigotes (IC50: 6.2 μg/ml) and amastigotes (IC50: 10.87 μg/ml) of Leishmania tropica. Brine shrimp lethality was also indicated by bioinspired ZnO nanoparticles (IC50: 21.29 μg/ml). Hemocompatible nature of bioinspired nanoparticles was revealed. Furthermore, the antioxidant activities were performed. In addition, significant protein kinase while insignificant alpha amylase inhibition were recorded.