Abstract
Intravenous hyperalimentation in chronically ill patients has become increasingly common in hospitalized patients. Total parenteral nutrition includes supply of carbohydrates, amino acids, and lipids. The safety of a new emulsion of safflower oil (Liposyn 10%) infused by peripheral vein was evaluated in 15 normal male volunteers. All subjects tolerated Liposyn infusion, with a low incidence of side effects, when given either as a single infusion or multiple daily infusions to provide 4% of daily caloric requirements in the form of linoleic acid for 5 consecutive days. In large doses, the lipid infusion was accompanied by a decrease in Lee-White clotting time in most subjects, and 1.5 to 2 U/ml of heparin added to the emulsion reversed this effect. Such mini doses of heparin also accelerated the breakdown and disappearance of triglycerides, with a resultant increase in serum free fatty acids and cholesterol. These data suggest that safflower oil emulsion can be used as a source of essential fatty acids for intravenous alimentation. It is also suggested that patients receiving lipid infusion should receive heparin to minimize risks associated with hypercoagulability of blood.
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