Abstract
Effects of dietary fats consisting of different fatty acids on the acetyl CoA-carboxylase activity in liver was studied in rats. Sprague-Dawley male rats were meal-fed an isoenergetic diet based on either beef tallow or safflower oil for 8 weeks. The acetyl CoA-carboxylase activity in liver was lower in the safflower oil diet group than in the beef tallow diet group. Body fat accumulation was less in rats fed the safflower oil diet, however, their norepinephrine turnover rate in liver was higher. α1-Adrenergic receptor binding was determined with [3H] prazosin. Binding affinity of α1-adrenergic receptor in liver was higher in the safflower oil diet group, presumably resulting from higher membrane fluidity in that group. These results suggest that the intake of the safflower oil diet promoted less body fat accumulation by reducing the acetyl CoA-carboxylase activity, which may be a result of higher sympathetic nervous system activity in the liver.
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