Abstract
AbstractBackgroundThe pathophysiology of neurodegenerative diseases, particularly Alzheimer’s disease is multifactorial. However, with scientific evidences suggesting that various antioxidants possess different protective mechanisms, thus hypothetically/theoretically no single natural compound can adequately abrogate these plethora of neurodegenerative cascades. Hence, there is a need for a paradigm shift from the usual monotherapy directed management of neurodegeneration. Therefore, this study investigated the effects of combined administration of three antioxidants namely; hesperetin, lycopene and ellagic acid in the brain of balb c mice.MethodThirty (30) male balb/c mice were grouped and administered orally with respect to each of their weights for Twenty eight (28) days as follows: Group I (Control)‐ Dimethyl sulfoxide (DMSO) in olive oil, Group II‐ Lycopene (5mg/kg body wt), Ellagic acid (15mg/kg body wt), Hesperetin (20mg/kg body wt) dissolved in DMSO and olive oil, Group III‐lycopene(10mg/kg body wt), Ellagic acid (30mg/kg body wt), Hesperetin(40mg/kg body wt) dissolved in DMSO and olive oil.ResultThe combination regimen at both doses show no significant difference in the concentration of nitric oxide (NO), protein carbonyl (PC), reduced glutathione (GSH), hydrogen peroxide (H2O2), malondialdehyde (MDA) level, activity of catalase (CAT) in the brain. Furthermore, the numbers of spared pyramidal and purkinje neurons of the cortex (sensorimotor cortex, hippocampus) and cerebellum at both doses were increased respectively but not significant when compared with their age‐matched control. Also, neuronal nuclei (NeuN) immunohistochemical staining revealed a slightly elevated matured neuronal population, as well as decreased ionized calcium binding adaptor molecule 1 (Iba1) expressions.ConclusionIn conclusion, this study suggests that the combined regimen is not only safe, but also enhanced cell viability in normal condition and could be promising in the management of neurodegenerative diseases.
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