Abstract
The safety profile of an extractive from Salacia reticulata (Celastraceae) trunk (SE) was examined using an oral single dose toxicity test and chromosomal aberration test. In the oral toxicity test, SD rats were given SE at a dose of 5, 000mg/kg. No deaths or abnormalities in gross pathological findings were observed during the study period. The rats given SE had diarrhea for a few days due to the pharmacological properties. Moreover, body weight gain was suppressed in both male and female rats given SE, compared to the controls, at 1 day after administration. In the chromosomal aberration test using cultured mammalian cells (CHL/IU), no cells with chromosomal aberrations were observed. These results suggest that SE has no serious acute toxicity or mutagenicity.
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