Abstract
The present study was taken up to evaluate the single dose acute toxicity, 28 days and 90 days repeated dose toxicity and reproductive/developmental toxicity of standardized 40% Garcinol in experimental rodents. The studies were conducted in compliance with OECD principles of good laboratory practice, guidelines for testing of chemicals no.420, 407, 408 and 421 respectively. Single dose acute oral toxicity was conducted on female Wistar rats as sighting study step-I (300 mg/kg) & sighting study step-II (2000 mg/kg) and main study (2000 mg/kg). Sub-acute, sub-chronic and reproductive/developmental studies were conducted in Wistar rats divided equally in vehicle control, 20, 50 and 100 mg/kg dose group along with recovery groups for vehicle control and high dose. Reproductive/developmental study was carried out for minimum of 28 days and in females during pregnancy and 4 days post partum. There were no abnormal clinical signs/behavioural changes, reproductive and developmental parameters, gross and histopathological changes as well as no alteration in the body weight, body temperature, haematology and other biochemical parameters in all the four studies. 40% Garcinol has a low toxicity profile in rodents and had no observed effects under experimental conditions used.
Highlights
Food and health are the two terms always associated with each other through ages and today life sciences contribute to explain it as characterized by complexity [1]
Garcinol (Crystallized yellow needles) chemically polyisoprenylated benzophenone derivative of molecular formula C38H50O6 (Fig. 1) with molecular weight of 602.39252 and melting point of 122 °C is obtained from Garcinia indica fruit rind [5,20]
The 40% Garcinol did not show any adverse effect at high single dose of 2000 mg/kg at acute safety study in Wistar rats and can be classified as GHS category 5/unclassified according to the Globally Harmonized classification system (GHS) for classification of chemicals
Summary
Food and health are the two terms always associated with each other through ages and today life sciences contribute to explain it as characterized by complexity [1]. Benefit of food beyond the basic nutritional value in prevention of disease and health enhancement using its elements is the interest of people today. Most of the bioactive components related to food products used daily, originated in plant are owed by the traditional medicinal practice [2]. Garcinia indica from Clusiaceae [4] family commonly known as Kokum is an evergreen plant native to Western Ghats of India but distributed throughout the tropical regions of India, Africa and China [5]. Ayurvedic system of medicine recommends its use in scurvy, rheumatism, oedema, sore, heat strokes, dermatological conditions, contagious diseases and as emollient and demulcent [7]
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