Abstract
In a mass immunization program, over 7.5 million doses of Sabin oral poliovaccine (OPV, types 1, 2, and 3) were administered in Los Angeles County in 1962 and 1963, during a period of declining and low enterovirus prevalence. Clinical and laboratory surveillance failed to demonstrate vaccine-associated illness. It seems highly unlikely that the 5 to 21 cases of paralytic poliomyelitis expected on the basis of "maximal expected risk" could have been overlooked. A reasonable explanation for the apparent disparity between Los Angeles County and certain other areas in safety of OPV is that other agents were present elsewhere which produced disease independently or in concert with OPV.
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