Abstract
The increasing use of ibuprofen for the treatment of fever in children has caused concern about possible toxic effects. In susceptible adults ibuprofen has caused kidney dysfunction. While it is unlikely that a child with known kidney disease would be given ibuprofen, many children with febrile illnesses are dehydrated. This report presents an analysis of pre- and poststudy observations from 2 clinical trials that compared the antipyretic effects of ibuprofen and paracetamol in 180 otherwise healthy febrile children.
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