Abstract
Safety of oil-based contrast medium for hysterosalpingography: a systematic review
Highlights
Hysterosalpingography (HSG) to assess tubal patency is an essential part of the workup for subfertile couples (National Institute for Health and Care Excellence, 2017)
Eligibility criteria All types of studies were included: randomized controlled trials (RCT), prospective and retrospective cohort studies, case series and case reports that report complications occurring during or after HSG with the use of oil-based contrast, with or without comparison to water-based contrast, in women trying to conceive or their offspring
This study identified case reports of pulmonary oil embolisms after HSG performed in patients with: tubal ligation (n = 2) (Roblee, 1945), suspected endometrium carcinoma (n = 1) (Breitländer and Hinrichs, 1941), abdominal pain (n = 1) (Ingersoll and Robbins, 1947), uterus myomatosus (n = 2) (Hodge and Price, 1969; Keller, 1943) and missed abortion (n = 1) (Hinaut et al, 1966)
Summary
Hysterosalpingography (HSG) to assess tubal patency is an essential part of the workup for subfertile couples (National Institute for Health and Care Excellence, 2017). From 1914 iodized oils were used as an alternative to the water-based contrasts, which were irritative to the peritoneum (Cary, 1914; Nielsen, 1946; Soules and Spadoni, 1982). Different iodized oils were introduced, such as Lipiodol®, Iodochlorol, Ethiodol, Jodipin, Jodumbrin and Lipiodol® Ultra Fluid. The oil-based contrasts available today are Lipiodol® Ultra Fluid (Guerbet, Villepinte, France) and Ethiodized Poppyseed Oil (Heng Rui Pharmaceuticals, Jiangsu, China), the latter being currently only available in Asia. In 1960 a transesterified version of Lipiodol was developed, Lipiodol Ultra Fluid, which had a lower viscosity (Bonnemain and Guerbet, 1995; Simescu et al, 2002)
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