Safety of moxidectin 1% injectable solution and 0.1% oral drench for lambs younger than one month

Abstract

Two hundred lambs, 4–29 days old, were segregated into eight groups; lambs in Group A were injected with a single dose of moxidectin 1% inj. sol. (0.2 mg kg −1 bodyweight), those in Group C were injected with a quadruple one (0.8 mg kg −1 bodyweight), those in Group E with a single dose of moxidectin 0.1% or. dr. (0.2 mg kg −1 bodyweight) and those in Group G with a decuple oral dose (2 mg kg −1 bodyweight); lambs in groups B, D, F and H were the controls. The reactions of lambs were recorded for 14 days after administration of the test product. The only adverse reaction observed was in one Group C lamb, which became indifferent to the environment and laid down in a corner of the pen after administration; this regressed within 12 h without any particular medical treatment of the lamb and was not statistically significant. It is concluded that moxidectin is safe for administration to young lambs.