Abstract

As new protocols are developed and treatment plans change, the demand for higher numbers of donor stem cells for patients has increased. This is especially true for non-myeloablative transplants where a higher cell dose may be needed to assure engraftment. There is a concern for safety in this donor population that elevated white blood cell counts may lead to altered blood flow kinetics, cause shortness of breath, decreased cerebral blood flow, and contribute to cardiac ischemia.

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