Safety of adenosine in stress cerebral perfusion imaging

Abstract

Objective To evaluate the safety of adenosine as pharmacological stress agents in stress cerebral perfusion imaging. Methods Eighty patients under investigation for suspected cerebral vessel disease were recruited. Each had a resting seen and a stress scan on different days. The adenosine stress protocol was as same as the protocol used in adenosine stress myocardial perfusion imaging. Subjective and objective side-effects were investigated during pharmacological stress procedure. Results All patients completed the 6 min infusion protocol without premature termination on safety criteria or due to intolerable symptoms. 46 patients had mild side effects. 20 patients (25%) had dizziness, 12 patients (15%) had palpitation, 1 patient (1%) was hypotensive, 7 patients (9%) had dyspnoea, 4 patients (5%) felt hot, 3 patients (4%) had sweat, 4 patients (5%) had nausea, 6 patients (8%) had flushing, 19 patients (24%) had chest pain, 6 patients (8%) had abdomen pain, 3 patients (4%) had abnormal taste and 1 patient (1%) were thirsty. Transient ST change occurred in only 1 patient. Conclusion Adenosine stress cerebral perfusion imaging is a safe diagnostic method with mild side effects. Key words: Adenosine; Brain; Tomography, emission-computed, single-photon; 99mTc-ethy cysteinate dimer