Abstract
Pharmacogenetics investigates the molecular basis of inter-individual differences in drug metabolism and response. Sequence variations in genes encoding for metabolic enzymes may influence drug’s pharmacokinetics and/or pharmacodynamics, resulting in reduced efficacy and/or adverse drug reactions. The dihydropyrimidine dehydrogenase (DPD) deficiency is a clear example of how gene variants may affect fluoropyrimidines metabolism, and its … Continued
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