Abstract
Purpose: Interstitial implant is an accepted technique for boost after conservative surgery (BCS) and whole breast radiotherapy (WBRT) in selected locally advanced breast cancer (LABC) after adequate downstaging by neoadjuvant chemotherapy. But as yet there is no clear consensus about optimal margin around tumor bed that should be considered as CTV for boost in LABC. Present study was aimed to explore the influence of tumor bed margin for HDR brachytherapy boost in LABC on local control, late toxicities and cosmetic outcome.
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