Abstract
BackgroundEffects of long-term glucose load on peritoneal dialysis (PD) patient safety and outcomes have seldom been reported. This study demonstrates the influence of long-term glucose load on patient and technique survival.MethodsWe surveyed 173 incident PD patients. Long-term glucose load was evaluated by calculating the average dialysate glucose concentration since initiation of PD. Risk factors were assessed by fitting Cox's models with repeatedly measured time-dependent covariates.ResultsWe noted that older age, higher glucose concentration, and lower residual renal function (RRF) were significantly associated with a worse patient survival. We found that female gender, absence of diabetes, lower glucose concentration, use of icodextrin, higher serum high density lipoprotein cholesterol, and higher RRF were significantly associated with a better technique survival.ConclusionsLong-term glucose load predicted mortality and technique failure in chronic PD patients. These findings emphasize the importance of minimizing glucose load in PD patients.
Highlights
MethodsGlucose is the main osmotic agents providing ultrafiltration (UF)to peritoneal dialysis (PD) patients [1], a high glucose load may cause peritoneal damage, hyperglycemia, hyperinsulinemia, dyslipidemia, oxidative stress, and increased incidences of metabolic syndrome, as well as cardiovascular diseases (CVD)[2,3,4]
We recently reported that higher initial glucose load, defined as the average dialysate glucose concentration prescribed in the first 6 months of PD therapy, predicted a worse PD
We identified that patients with diabetes mellitus (DM), high body mass index (BMI), and low residual renal function (RRF) tend to have a high dialysate glucose load during long-term PD therapy [5]
Summary
MethodsGlucose is the main osmotic agents providing ultrafiltration (UF)to peritoneal dialysis (PD) patients [1], a high glucose load may cause peritoneal damage, hyperglycemia, hyperinsulinemia, dyslipidemia, oxidative stress, and increased incidences of metabolic syndrome, as well as cardiovascular diseases (CVD)[2,3,4]. We identified that patients with diabetes mellitus (DM), high body mass index (BMI), and low residual renal function (RRF) tend to have a high dialysate glucose load during long-term PD therapy [5]. Regarding long-term patient safety, the accumulative effects from glucose load have rarely been reported. In this retrospective 7-year cohort study of chronic PD patients, we analyze the accumulative effects of longterm glucose load on patient outcomes by applying repeatedly measured time-dependent covariates in survival analysis. Effects of long-term glucose load on peritoneal dialysis (PD) patient safety and outcomes have seldom been reported. This study demonstrates the influence of long-term glucose load on patient and technique survival
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
