Safety indices from iliac crest biopsies from postmenopausal osteoporotic women after 36 months of treatment with PTH (1–84)

Abstract

detected in osteocytic lacunar walls in cortical bone, the lower affinity compound appeared to penetrate the osteocyte network further from the bone surface or from vascular channel walls than the higher affinity BP. These observations support our hypothesis that mineral affinity can influence the distribution of BPs and related analogues, both on bone surfaces and within the osteocyte canalicular network. Conflict of interest: CE Mckenna, Procter and Gamble, grant research support. CE McKenna, Procter and Gamble, consultant. MJ Rogers, Procter and Gamble, Roche, Novartis, grant research support.