Abstract
Human peripheral blood mononuclear cells (PBMC) are widely used within tissue engineering therapy, thus, the evaluation of their safety is mandatory. The present study aims to assess the safety of human PBMC transplantations in naive rats in terms of chronic toxicity. Rats received intravenous injections of human PBMC with doses of 105, 106, or 107 cells (n = 5/group/sex) every month for three months without administration of any immunosuppressant drugs. We evaluated clinical, physical, laboratory, and pathology parameters. No morbidity, mortality, or significant differences occurred within all of the tested parameters between control and experimental groups until the finalization of the study. In conclusion, the current work indicates that human PBMC transplantation in naive rats did not induce chronic toxicity reaction. Bangladesh Journal of Medical Science Vol. 21 No. 02 April’22 Page : 373-383
Highlights
Tissue engineering techniques are widely employed within therapies for several diseases
peripheral blood mononuclear cells (PBMC) has been widely used as a diagnostic tool, it is predicted that these cells may provide additional benefits to cure diseases, especially in tissue engineering therapy
We found that human PBMC transplantations were tolerated well in naive rats, and thereby demonstrated that human PBMC administration was safe for these animals
Summary
Tissue engineering techniques are widely employed within therapies for several diseases. The primary component of this technique involves mononuclear cells (MC); MC transplantation is increasingly being used in tissue engineering therapy 1. Objective: To obtain preliminary data on the use of bone marrow mononuclear cells The aforementioned engineered animals were not available in our country, secondly, these animals are
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