Abstract
This study was designed to elucidate the acute toxicity of Artocarpus altilis leaf and bark extracts. In acute toxicity study, no mortality or any toxic reaction was recorded in any group after 14 days of administering the extracts (2000 mg Kg−1 BW). The extracts (ALA, ABA, ALM, and ABM) did not cause any behavioural or physical changes in experimental rats. There was no significant (P ≤ 0.05) difference in the biochemical parameters analysed between the groups. Slight elevation in activities of AST and ALT in extract treated groups was observed, but this did not exert any deleterious effect on the normal metabolism which was supported by the histopathology of liver. Histopathological studies showed no remarkable changes after 14 days of oral administration of ALA, ABA, ALM, and ABM extracts. The study contributes to establishing the nontoxic quality parameters of Artocarpus altilis leaf and bark parts and the results suggest the safety of the extracts in therapeutic uses.
Highlights
India has an ancient heritage of traditional medicine
Bioactive compounds derived from medicinal plants can be useful but might have serious dose-related side effects
In the present acute toxicity study of different A. altilis leaf and bark extracts, the animals were treated with limit test dose of 2000 mg−1 kg BW (OECD guidelines 420, 2001)
Summary
India has an ancient heritage of traditional medicine. According to a survey by WHO, it is estimated that about 80% of people living in developing countries rely on traditional plant-based medicine for their basic health care needs [1, 2]. The results are used in combination with the efficacy of bioactives to decide whether the beneficial effects of the treatment would outweigh the risks of adverse side effects, if any, and to establish a safe dose for use in clinical trials [7]. These medicinal plants/metabolites can be safely utilized as nutraceutical or can be incorporated into food formulation as functional ingredient
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