Abstract
Marbofloxacin (MB) is an extended spectrum, third generation fluoroquinolone, developed exclusively for the use in veterinary medicine. The safety assessment was done to evaluate the clinical impact of marbofloxacin after repeated intramuscular administration in goats. Safety of drugs is important and changes in serum biochemical and/or hematological markers could provide an early indication of cellular toxicity. The drug was administered at the dose of 2 mg/kg for 5 days by intramuscular route in six healthy, non-lactating Beetal goats, 1.5-2 yrs of age. Haematological (TLC, TEC, Hb, PCV, MCV, MCH and MCHC) and serum biochemical parameters viz. liver function test (LFT) and kidney function test (KFT) (ALT, AST, ALP, GGT, BUN, creatinine, total proteins and albumin) were determined and analyzed to establish the safety profile of marbofloxacin. The hematological and biochemical parameters were found to fluctuate within normal range during treatment period and no significant alterations (p < 0.05) were found in the mean values. The results indicated that intramuscular administration of marbofloxacin in goats at the dose of 2 mg/kg for 5 days seems to be safe.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Toxicology International (Formerly Indian Journal of Toxicology)
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
