Abstract
Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is the commonest inherited disorder of the kidneys. A vasopressin V2-receptor antagonist (tolvaptan) was recently approved for the treatment of ADPKD. This study aims to analyze the safety and tolerability of tolvaptan for the management of ADPKD patients in a real-world setting.Methods: We conducted a descriptive retrospective study in ADPKD patients in an outpatient clinic setting in Spain from 2018 to 2019. Descriptive statistical analysis of demographics and clinical data, at baseline and one year after tolvaptan initiation, was assessed. Data are presented as median and interquartile range, and as frequencies for categorical variables.Results: Ten patients with ADPKD were identified. At baseline median age was 49.5 (38.5-63.5) years and 60% were males. During treatment with tolvaptan, no significant aquaresis-related symptoms or hepatotoxicity were described. No serious adverse events, discontinuation, or deaths were reported during the study.Conclusion: Tolvaptan was well-tolerated without severe adverse events in patients with ADPKD who showed rapid disease progression criteria. Longer follow-up is required to learn about the long-term effects of this treatment.
Highlights
Autosomal dominant polycystic kidney disease (ADPKD) is the commonest inherited disorder of the kidneys
ADPKD is characterized by mutations in polycystic kidney disease 1 (PKD1), polycystic kidney disease 2 (PKD2) and glucosidase II alpha subunit (GANAB) genes that increase the cyclic adenosine monophosphate intracellular levels and upregulate the mammalian target of rapamycin receptor
Tolvaptan showed a reduction in kidney volume, decrease in the slope of serum creatinine and glomerular filtration rate worsening while reducing the frequency of ADPKD-related complications derived from large kidney volume
Summary
Autosomal dominant polycystic kidney disease (ADPKD) is the commonest inherited disorder of the kidneys. Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited disorder of the kidneys. ADPKD is characterized by mutations in polycystic kidney disease 1 (PKD1), polycystic kidney disease 2 (PKD2) and glucosidase II alpha subunit (GANAB) genes that increase the cyclic adenosine monophosphate (cAMP) intracellular levels and upregulate the mammalian target of rapamycin receptor (mTOR). These abnormalities result in the development and enlargement of kidney cysts and cell proliferation, leading to ESRD. Patients with ADPKD could have safety or tolerability concerns like increased thirst, concurrent comorbidities, major side effects leading to non-compliance with therapies, or taking therapies likely to interfere with tolvaptan
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.