Abstract
Immune responses to meningococcal conjugate (Menactra™; MCV-4) and plain polysaccharide (Menomune®-A/C/Y/W-135; PSV-4) vaccines against serogroups A, C, Y, and W-135 were assessed in 220 of 1037 Chilean children aged 2 to 10 years participating in a comparative safety trial. Both vaccines were generally well tolerated. Geometric mean serum bactericidal antibody (SBA) titers 28 days postvaccination were comparable in both groups for all four serogroups. Seroconversion was evident in >97% of MCV-4 and >90% of PSV-4 vaccinees who tested seronegative at baseline. Menactra™ safely induced broad and robust immune responses against serogroups A, C, Y, and W-135 in this population.
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