Abstract
BackgroundTo evaluate the safety and efficacy of using a lid hygiene brush prototype to wipe the lid margins with lid hygiene shampoo in subjects with normal meibomian glands.MethodsTwelve eyes of 6 subjects were all evaluated just before and after wiping lid margins using 1) tap water alone, 2) Eye Shampoo, 3) Eye Brush, or 4) both products, each during a different week. The results after using both products twice daily for 1 month were also evaluated. Wiping efficacy was determined by post-wiping scores for the remaining fluorescein-stained 0.3% Tarivid ointment fully applied to eyelids and lid margins under microscopic view illuminated by blue light just after performing each of the four lid hygiene methods described above.ResultsNo significant deterioration in ocular conditions occurred. Eyestrain, eye discharge, and dryness decreased with tap water (P = 0.020), Eye Shampoo (P = 0.036), and Eye Brush (P = 0.014), respectively. Sensations of eye discharge increased after 1 month of using both products (P = 0.042). The wiping efficacy of Eye Brush, Eye Shampoo or both was significantly greater than that of tap water alone (two-sided test, P = 0.003, 0.003, 0.002), and using both significantly increased efficacy above Eye Shampoo use alone (one-sided test, P = 0.009).ConclusionsWiping lid margins using Eye Brush enhanced the cleansing power of Eye Shampoo. A daily healthcare routine using both products could be a safe and effective option for daily lid hygiene.Trial registrationUMIN000016905. Registration date: March 24, 2015; the study was prospectively registered.
Highlights
To evaluate the safety and efficacy of using a lid hygiene brush prototype to wipe the lid margins with lid hygiene shampoo in subjects with normal meibomian glands
Evaluation of safety There was no significant deterioration in tear break-up time (TBUT), corneal and conjunctival staining scores, lid-margin staining scores or DR-1 scores after any method (Figs. 3, 4, 5, 6 and 7, Additional file 1, 2, 3 and 4)
Eyestrain Visual analog scale (VAS) scores significantly decreased with tap water (23.5 (0–25) to 0 (0–0), P = 0.020) (Fig. 3, Additional file 1), eye discharge significantly decreased with Eye Shampoo use (3 (0–9) to 0 (0–1.25), P = 0.036) (Fig. 4, Additional file 2), and dryness decreased with Eye Brush use (12.25 (0–21.25) to 0 (0–5), P = 0.014) (Fig. 5, Additional file 3)
Summary
To evaluate the safety and efficacy of using a lid hygiene brush prototype to wipe the lid margins with lid hygiene shampoo in subjects with normal meibomian glands. Several lid hygiene products have emerged for the prevention or treatment of ocular diseases in response to the increased prevalence of new eye cosmetics and an improved understanding of the importance of lid hygiene [1–7]. Eye Shampoo (MediProduct Co., Ltd., Tokyo, Japan) is one of those options [6, 7]. We developed a lid hygiene brush prototype (Eye Brush) similar to a toothbrush and evaluated the safety and efficacy of using it
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