Abstract
In India, brucellosis a re-emerging disease, is of public health and economic concern to dairy industry. Brucella abortus strain-19 vaccine is recommended as most effective vaccine for cattle and buffaloes, however application of full dose is restricted in adults due to persistence of antibody response that interfere with serological diagnosis. In the present study 120 seronegative female cattle (60 calves and 60 young heifers each in a group) were subjected for vaccination. In each age group, 40 animals were vaccinated subcutaneously with a reduced dose of B. abortus S-19 vaccine, 10 animals with standard dose and 10 animals served as controls. Animals were observed for local or systemic reactions after vaccination as well as during study period. Blood samples were collected on day 0, 21, 60, 90 post-vaccination for antibody response and cell mediated immunity (CMI). The study revealed that the reduced dose vaccine is safe with satisfactory humoral and CMI response comparable to that of the standard dose, in both the age groups of animals when administered subcutaneously. It was concluded that the B. abortus S-19 reduced dose vaccine is safe and effective in the young and non-pregnant cattle up to the age of 30 months.
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