Safety and efficacy of post-haematopoietic cell transplantation maintenance therapy with blinatumomab for relapsed/refractory CD19-positive B-cell acute lymphoblastic leukaemia: protocol for a phase I–II, multicentre, non-blinded, non-controlled trial (JPLSG SCT-ALL-BLIN21)

Hirotoshi Sakaguchi,Hiromasa Yabe,Akiko Saito,Keizo Horibe,Souichi Adachi,Hidefumi Hiramatsu,Masashi Sanada,Yuta Kawahara,Itaru Kato,Kimiyoshi Sakaguchi,Katsustugu Umeda,Hisashi Noma,Hiroyuki Ishida,Takashi Taga,Takao Deguchi,Hiroaki Goto,Yuka Iijima Yamashita,Yoshiyuki Takahashi

doi:10.1136/bmjopen-2022-070051

Safety and efficacy of post-haematopoietic cell transplantation maintenance therapy with blinatumomab for relapsed/refractory CD19-positive B-cell acute lymphoblastic leukaemia: protocol for a phase I–II, multicentre, non-blinded, non-controlled trial (JPLSG SCT-ALL-BLIN21)

Hirotoshi Sakaguchi, Hiromasa Yabe + Show 16 more

Open Access

https://doi.org/10.1136/bmjopen-2022-070051

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Journal: BMJ Open	Publication Date: Apr 1, 2023
Citations: 2	License type: open-access

Affiliation: National Center For Child Health and Development, Tokai University, Nagoya Medical Center, National Hospital Organization, Kyoto University, Jichi Medical University, Hamamatsu University School of Medicine, The Institute of Statistical Mathematics, Kyoto City Hospital, Shiga University of Medical Science, Kanagawa Children's Medical Center, Nagoya University

#Children, Adolescents And Young Adults #Refractory B-cell Acute Lymphoblastic Leukaemia + Show 8 more

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Abstract

IntroductionRelapsed and refractory B-cell acute lymphoblastic leukaemia (R/R-B-ALL) is linked to a significant relapse rate after allogeneic haematopoietic cell transplantation (allo-HCT) in children, adolescents and young adults (CAYA). No standard...

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