Abstract
PURPOSE: Intrapleural instillation of Streptokinase and Urokinase has been utilized in the management of loculated pleural effusions associated with pleural sepsis and pleural clots. Both of these agents are less readily available for use due to the increasing use of Alteplase for fibrinolysis. We studied the use of Alteplase in the management of three cases of clotted hemothorax to assess both efficacy and safety of this agent.
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