SAFETY AND EFFICACY OF CONCOMITANTLY USED DIRECT ORAL ANTICOAGULANT AND AMIODARONE IN PATIENTS WITH NON-VALVULAR ATRIAL FIBRILLATION: A META-ANALYSIS OF PROSPECTIVE RANDOMIZED CLINICAL TRIALS

Abstract

Direct oral anticoagulants (DOACs) and amiodarone are widely used in the treatment of non-valvular atrial fibrillation (NVAF). The DOACs are P-glycoprotein (P-gp) and cytochrome p-450 (CYP3A4) substrates. DOAC levels may be increased by the concomitant use of potent dual P-gp/CYP3A4 inhibitors such