Abstract
This study was designed to determine the safety and efficacy of cefovecin (Convenia?; Pfizer Animal Health) when compared to clindamycin (Antirobe?; Pfizer Animal Health) as an adjunctive therapy to periodontal scaling or surgery for severe periodontal disease in dogs. A multi-centre, double-masked, randomised study was conducted in 299 dogs with severe periodontal disease. Clindamycin, administered once daily at 11 mg/kg bodyweight orally for 10 days following dental surgery was compared with a single, subcutaneous injection of cefovecin (8 mg/kg bodyweight) administered at the time of dental surgery. The primary efficacy parameter assessed was percentage of tooth-root sites bleeding when probed (an indicator of gingival inflammation) 42 days after surgery. Two-hundred and ninety-one (291) dogs were included in the efficacy assessments. Cefovecin was shown to be non-inferior to clindamycin. The percentage of sites bleeding on probing was reduced from 54.3% to 20.3% for the cefovecin group (53.1% reduced to 17.4% for the clindamycin group). There were no suspected adverse drug experiences attributed to treatment with cefovecin or clindamycin. Cefovecin was shown to be as effective and safe adjunctive treatment for severe periodontal disease in dogs undergoing periodontal scaling and surgery as clindamycin.
Highlights
Periodontal disease is the most common dental infection in dogs [1]
Clindamycin, administered once daily at 11 mg/kg bodyweight orally for 10 days following dental surgery was compared with a single, subcutaneous injection of cefovecin (8 mg/kg bodyweight) administered at the time of dental surgery
The percentage of sites bleeding on probing was reduced from 54.3% to 20.3% for the cefovecin group (53.1% reduced to 17.4% for the clindamycin group)
Summary
Periodontal disease is the most common dental infection in dogs [1] It is caused by the accumulation of plaque and an associated change in periodontal bacterial flora (from commensal aerobic to pathogenic anaerobic bacteria such as Porphyromonas spp. and Prevotella spp) [2-5]. Periodontal disease is a collective term for a number of inflammatory conditions affecting the periodontium around the tooth (attached gingiva, periodontal ligament, cementum of the root and alveolar bone). It progresses from reversible gingivitis, characterised by inflamed and often bleeding gingiva, to periodontitis with the associated inflammatory tissue damage, the formation of deep periodontal pockets or gingival recession, loss of epithelial attachment and bone resorption. Bacteraemia may even occur during minimal mechanical disturbance, such as normal mastication, without any pro-
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