Abstract
We assess the efficacy and safety of canaloplasty and trabeculectomy for treatment of glaucoma. We searched the China National Knowledge Infrastructure, PubMed, Web of Science, and WanFang databases for potentially eligible studies. Pooled risk ratio (RR) with 95% confidence interval (CI) was calculated using random- or fixed-effect models if appropriate. Eight studies were included for meta-analysis. There was no difference in intraocular pressure at 6 months (WMD = 0.97, 95%CI: -0.48-2.41). Intraocular pressure in canaloplasty group 12 months after operation was higher than in trabeculectomy group (WMD = 1.90, 95%CI: 0.12-3.69), P < 0.05). The canaloplasty group showed higher success rate than trabeculectomy group (RR = 0.86, 95%CI: 0.77-0.97). The canaloplasty group was more likely to have hyphema (RR = 2.96, 95%CI: 1.51-5.83), P < 0.05) than trabeculectomy group (RR = 0.24, 95, CI(0.06-0.89), P < 0.05]. The incidence of and hypotony and postoperative choroid abnormalities in canaloplasty group was significantly lower than that in trabeculectomy group (RR = 0.30, 95%CI: 0.11-0.83; RR = 0.24, 95%CI: 0.09-0.66), P < 0.05). Both trabeculectomy and canaloplasty can significantly reduce the intraocular pressure in glaucoma patients at 12 months after operation, trabeculectomy leads a more marked IOP decrease than canaloplasty at the cost of a higher complication rate and more demanding for postoperative care.
Highlights
Trabeculectomy has long been considered to be the gold standard procedure of lowering intraocular pressure in patients with glaucoma [1, 2]
The present study found that trabeculectomy could reduce the intraocular pressure more obviously than canaloplasty at 12 months after operation
Trabeculectomy group have higher succus rate of intraocular pressure control while canaloplasty group are more likely to have hyphema compared with trabeculectomy group, but less possible to have hypotony and choroidal detachment
Summary
Trabeculectomy has long been considered to be the gold standard procedure of lowering intraocular pressure in patients with glaucoma [1, 2]. It involves draining aqueous humor from the anterior chamber into the subconjunctival spaces through a sclerostomy and requires full-thickness penetration of the anterior chamber under a partial-thickness scleral flap [3]. We performed a meta-analysis to compare the www.impactjournals.com/oncotarget safety and efficacy of canaloplasty versus trabeculectomy in treatment of glaucoma. We hope this results could provide some support for clinical practice
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