Abstract
Objective To assess the efficacy and safety of Seasonique™, a 91-day extended-regimen oral contraceptive (OC) utilizing continuous low-dose ethinyl estradiol (EE) during the typical hormone-free interval. Methods A multicenter, open-label, 1-year study of Seasonique™ [30 μg EE/150 μg levonorgestrel (LNG)] for 84 days followed by EE 10 μg for 7 days was conducted in sexually active, adult women of childbearing potential. All patients completed daily electronic diaries to monitor compliance and bleeding. Results Method failure rate was 0.78 (Pearl index) and 0.64% (life table analysis). Cycle control and safety of the regimen were similar to that reported for other OCs. Conclusion This study demonstrates that Seasonique™ is effective, safe and well tolerated for the prevention of pregnancy.
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