Abstract
Combined vaccines containing non-cellular pertussis component and having low reactogenicity, increase vaccination coverage against controllable infections. However, the safety of vaccination in children dealing with health issues, as well as those having a history of premature infancy, requires additional research. The article presents reactogenicity analysis for the DTP-IPV/HIB pentavaccine during primary vaccination and revaccination of premature infants (n = 85), as well as vaccination of mature newborns (n = 1433) inoculated in accordance with the national Vaccination Calendar behind the schedule. The occurrence of post-vaccinal reactions in the premature infant group was the same as in the mature infant group and amounted to 41.2% and 45.0%; the occurrence of common reactions was 18.8% and 22.4%; local effects measured 25.8% and 27.9% respectively. Post-vaccinal reactions were either weak or moderate, not requiring treatment, and they would completely disappear by the end of the third post-vaccinal day. Simultaneous injection of pentavaccine and Hepatitis B vaccine and pneumococcal conjugate vaccine in children with a history of premature infancy, showed no influence during the post-vaccinal period. The reactogenicity of pentavaccine increased along with the vaccination ratio during the primary series of vaccinations.
Highlights
ВВЕДЕНИЕ Постоянное усовершенствование прививочных программам позволяет контролировать основные инфекционные заболевания, в т. ч. угрожающие жизни детей раннего возраста [1,2,3]
The safety of vaccination in children dealing with health issues, as well as those having a history of premature infancy, requires additional research
Post-vaccinal reactions were either weak or moderate, not requiring treatment, and they would completely disappear by the end of the third post-vaccinal day
Summary
VП/ГВ — вакцина против вирусного гепатита В, VП/ПИ — вакцина против пневмококковой инфекции. Выражены: гиперемия и припухлость в месте инъекции появились у небольшого числа детей и не превышали в диаметре 6–7 см. У некоторых детей одновременно регистрировали как общую, так и местную реакцию. Что в группе детей, рожденных недоношенными, по сравнению со здоровыми детьми в поствакцинальном периоде чаще (р > 0,05) встречались снижение аппетита и длительный (> 2 ч) плач. По другим показателям переносимость пятивалентной вакцины у детей в сравниваемых группах была сопоставимой В группе недоношенных детей оценивали переносимость сочетанного введения пятивалентной вакцины с вакцинами против гепатита В и конъюгированной вакциной против пневмококковой инфекции. Увеличения реактогенности пентавакцины в результате совместного ее. Частота развития местных и общих реакций у здоровых детей и детей, родившихся недоношенными, при различной кратности введения пентавакцины АаКДС-ИПВ/ХИБ
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