Abstract
Throughout the EU funded FP7 project GUIDENano, we are trying to control and monitor the evolution of nano-enable products during their lifecycle. Small alterations of the nanoparticle (NP) state may have critical consequences on the NP behaviour and performance. For this reason it is important to highlight the importance of an extensive and proper characterization to define the NP physico-chemical characteristics under several environmental conditions. Furthermore, this characterization is necessary to ensure that obtained results are reproducible and allow understanding the behaviour of the NP on biological systems. In this paper different strategies reported in the literature regarding the safety-by-design concept are summarized. Several strategies from the synthetic point of view that help us to modulate the main factors which determine the safety of nanomaterials are proposed.
Highlights
The growing interest in the field of nanotechnology leads to an increase in the number of nanoparticles (NPs) producers and users, making indispensable the promotion of safe strategies in the development and management of nanomaterials (NMs).[1,2,3] the rise of the production of NPs is estimated on thousands of tons by 2020,4 accompanied by the increase of congresses, publications and research projects related to nanosafety in the last 10 years,[5] and reflected in the increasing number of nano-enabled products that reach the market
Some concerns have been arisen over current uncertainties on the safety of such products and they need to be carefully addressed to avoid human and environmental damage which could hinder the development of the nanotechnology field
The importance of a proper and extensive characterization to understand and control possible variations on the starting material is crucial in the development of improved nano-sized materials (NM).[22]
Summary
The growing interest in the field of nanotechnology leads to an increase in the number of nanoparticles (NPs) producers and users, making indispensable the promotion of safe strategies in the development and management of nanomaterials (NMs).[1,2,3] the rise of the production of NPs is estimated on thousands of tons by 2020,4 accompanied by the increase of congresses, publications and research projects related to nanosafety in the last 10 years,[5] and reflected in the increasing number of nano-enabled products that reach the market.
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