Safe Measles, Mumps and Rubella Vaccine Administration in Atopic Children with High Levels of Egg White-Specific IgE Antibody

Abstract

Aim: To present our clinical experience vaccinating egg allergic patients with a regular triple viral vaccine. Material and Methods: Twenty seven children with atopic dermatitis and high levels of egg whitespecific IgE antibody were recruited. The patients were selected in two groups: group without history of allergic reaction to egg consumption and group with convincing history of egg allergic reaction. In children aged less than 13 months open food challenge test was performed. Results: Thirteen children without history of allergic reaction to egg received ambulatory MMR immunization with no reaction. Fourteen children with convincing history of egg allergy, aged under 13 months had not been vaccinated, and they underwent open food challenge test in the hospital. They had increased IgE specific antibodies to egg white allergen and six of them had increased specific IgE to yolk. Nine children had history of mild to moderate allergic reaction while five had severe allergic reaction. Open food challenge test was performed. Eleven children with negative food challenge test were immunized in hospital; none had an adverse reaction. Three of them had positive food challenge test and due to anxiety of the parents the immunization was dallied at age of 2 years. One of them had worsening of the eczema; the two other had no adverse reaction. Conlusion: The measles, mumps and rubella vaccine can be safely administered ambulatory to children with atopic dermatitis allergic to eggs.