Abstract
Bongkrekic acid (BA) is a colorless and tasteless toxic. It exists in some fermented food and can be easily taken in by accident. Currently, no proper treatment has not been developed to treat this toxin in human body, therefore the death rate is very high. Mechanism of BA has been well studied these years and found that BA inhibit ATP synthesis, which lead to severe clinical symptoms, such as limb soreness, weakness and liver damage. In this paper, we mainly focus on the mechanism of BA in our human body, its related cases and the inhibition of BA in the food. This review can provide basic information for the future development of the treatment of BA in human body.
Highlights
Bongkrekic acid (BA) is a sort of fatty acid produced by the bacterium Burkholderia gladioli pv
The food can be contaminated by Burkholderia gladioli pathovar cocovenenans (B. cocovenenans) which can produce at least two poisonous substances, bongkrek acid(BA) and toxoflaxin(TF)
The effect of lipid concentration and fatty acid type on the production of BA by B. cocovenenans was examined by adding different amounts of coconut fat or individual free fatty acids to defatted and sterilized Rich Coconut Media(Garcia, R.A. et al, 1999) ‘Forty and 50% coconut fat resulted in as much as 1.4 mg/g BA at the same level of growth
Summary
Bongkrekic acid (BA) is a sort of fatty acid produced by the bacterium Burkholderia gladioli pv. It is best for people to understand how BA works as a mitochondrial toxin, why consuming fermented corn and coconut products causes BA related food poisoning, what serious symptoms are and how to inhibit BA. Oxygen uptake in sheep heart tissue, along with lactate accumulation and acidosis This illustration of BA site of action shows the inhibition of ATP translocase in the mitochondria matrix membrane, (as shown in the Figure 1), the cytoplasmic side of the carriernis closed by conserved hydrophobic residues. Solute transport across the impermeable mitochondria inner is essential for the function of survival of eukaryotic cells. This diffusion is catalyzed by membrane proteins. BA interferes with the transport process of ADP and hinders the exchange of ADP and ATP between the mitochondrial inner membrane to produces toxic effects, which directly affect the energy supply of biological cells
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
