Safe choice of metals in food bioprocess enzyme-mimicry?

Abstract

RNA hybrids with DNA immobilized on a membrane. J. Mol. Biol. 12, 829–842 6 Noyes, B.E. and Stark, G.R. (1975) Nucleic acid hybridization using DNA covalently coupled to cellulose. Cell 5, 301–310 7 Southern, E.M. (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis. J. Mol. Biol. 98, 503–517 8 Tyagi, S. and Kramer, F.R. (1996) Molecular beacons: probes that fluoresce upon hybridization. Nature Biotechnol. 14, 303–308 9 Vet, J.A.M. et al. (2002) Molecular beacons: colorful analysis of nucleic acids. Expert Rev. Mol. Diagn. 2, 77–86 10 Simeonov, A. and Nikiforov, T.T. (2002) Single nucleotide polymorphism genotyping using short, fluorescently labeled locked nucleic acid (LNA) probes and fluorescence polarization detection. Nucleic Acids Res. 30, e91 11 Koshkin, A.A. et al. (1998) LNA (locked nucleic acid): an RNA mimic forming exceedingly stable LNA:LNA duplexes. J. Am. Chem. Soc. 120, 13252–13253 12 Braasch, D.A. and Corey, D.R. (2001) Locked nucleic acid (LNA): finetuning the recognition of DNA and RNA. Chem. Biol. 8, 1–7 13 Nielsen, P.E. et al. (1991) Sequence selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Science 254, 1497–1500 14 Demidov, V.V. (2002) PNA comes of age: from infancy to maturity. Drug Discov. Today 7, 153–155 15 Demidov, V.V. (2002) New kids on the block: emerging PNA-based DNA diagnostics. Expert Rev. Mol. Diagn. 2, 89–91 16 Demidov, V.V. (2001) PD-loop technology: PNA openers at work. Expert Rev. Mol. Diagn. 1, 343–351 17 Svanvik, N. et al. (2000) Light-up probes: thiazole orange-conjugated peptide nucleic acid for detection of target nucleic acid in homogeneous solution. Anal. Biochem. 281, 26–35 18 Isacsson, J. et al. (2000) Rapid and specific detection of PCR products using light-up probes. Mol. Cell. Probes 14, 321–328 19 Svanvik, N. et al. (2001) Free-probe fluorescence of light-up probes. J. Am. Chem. Soc. 123, 803–809 20 Gaylord, B.S. et al. (2002) DNA detection using water-soluble conjugated polymers and peptide nucleic acid probes. Proc. Natl Acad. Sci. USA 99, 10954–10957 21 Okamoto, A. et al. (2002) Site-specific discrimination of cytosine and 5methylcytosine in duplex DNA by peptide nucleic acids. J. Am. Chem. Soc. 124, 10262–10263 22 Kuhn, H. et al. (2002) Hybridization of DNA and PNA molecular beacons to single-stranded and double-stranded DNA targets. J. Am. Chem. Soc. 124, 1097–1103