Sacral Neuromodulation in Male Sexual Dysfunction – A Systematic Review

Abstract

Introduction: Contemporary patient care requires full consideration of sexual health as well. Sexual dysfunction has a high prevalence and significantly affects quality of life. The cost to the health care system is estimated to be high but has not yet been calculated with certainty. Therapy considers sexual appetence, sexual arousal, orgasmic experience in both genders, lubrication in women and erection in men. Sacral nerve stimulation (SNS) has been used primarily for neurogenic bladder dysfunction, idiopathic pelvic pain, nonobstructive urinary retention, and fecal incontinence. Effects have also been observed on various components of sexual function. Sexual function as a primary outcome parameter of SNS has not been studied to date. Methods: For a systematic literature search, the Healthcare Databases Advanced Search (HDAS) platform was used, employing the Medline, EMBASE, and CINHAL search engines, and considering only publications from international peer-reviewed journals. Results: We identified 16 studies with inclusion of a total of 662 women and 40 men in which potential effects of SNS on sexual function were noted when used in other indications. For the female sex, there was evidence for significant improvements in sexual function. The very weak data situation for the male sex so far only allows to assume similar effects. In any case, it remains unclear whether these effects are primary or secondary to SNS. Discussion: SNS affects urinary bladder emptying, urinary bladder continence, pelvic pain, and fecal continence and defecation. The direct anatomical and physiological relationship between these organ systems and sexual function raises the question of whether there is a primary effect of SNS on sexual function. High-quality studies with sexual function as the primary endpoint should verify this.