Abstract
Bioethanol is produced by the fermentation of sugar-based, starch-based, or cellulosic renewable materials, and is currently blended into gasoline as a source of green fuel. Glutathione (GSH) is usually used in treatment of toxic hepatitis, ameliorate diseases of cornea and retina, detoxification of organics and heavy metals, and protection on radiotherapy and chemotherapy of tumors. Nowadays, GSH is also widely used in cosmetic and food processing industry. This study has been screened a hybrid yeast strain, Saccharomyces cerevisiae GSHOL2, which can produce both of ethanol and GSH. Process optimization of fermentative productions of ethanol and GSH by Saccharomyces cerevisiae GSHOL2 has been discussed. The ca. 11.6% (wt%) ethanol and 18.7 mg/g-DCW GSH can obtain after producing GSH for 48 hrs followed by ethanol produced for 48 hrs with fed-batch and batch fermentation in sequence. On the contrary, intracellular concentration of GSH can be improved by suitable addition of hydrogen peroxide after stationary phase due to the reason that hydrogen peroxide is still harmful to yeast cells. The results can not only increase additional economic values but also reduce the total cost of production. Moreover, it can also be used as a reference for commercialization in the future.
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